Mutation in Kras Codon 13, but not in Codon 12, Correlates with Poor Prognosis in Colorectal Cancer: a Cohort Study

KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran

Background & objective: KRAS mutations are reported in many types of cancers including pancreas, lung, colon, breast, and gastric (GC). High frequency of KRAS mutation is observed in the pancreas, colon, and lung cancers; they commonly arise in codon 12 and 13 of exon 2. Due to the lack of information about the frequency of KRAS</...

KRAS exon 2 codon 13 mutation is associated with a better prognosis than codon 12 mutation following lung metastasectomy in colorectal cancer

INTRODUCTION The utilization of molecular markers as routinely used biomarkers is steadily increasing. We aimed to evaluate the potential different prognostic values of KRAS exon 2 codons 12 and 13 after lung metastasectomy in colorectal cancer (CRC). RESULTS KRAS codon 12 mutations were observed in 116 patients (77%), whereas codon 13 mutations were observed in 34 patients (23%). KRAS codon ...

mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

Prognostic value of KRAS codon 13 gene mutation for overall survival in colorectal cancer

BACKGROUND The clinical significance of KRAS codon 13 mutation in patients with colorectal cancer (CRC) remains controversial. A systematic review and meta-analysis is necessary for a more precise estimation of the predictive role of KRAS codon 13 mutations in CRC patients. METHODS We performed a systematic search using the MEDLINE, EMBASE, and Cochrane library databases from January 2000 to ...

Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF-wild-type Colorectal Cancers Running title: KRAS Codon 12 and Codon 13 Mutations in Colorectal Cancer

1 Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; 2 Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA; 3 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA; 4 Department of Pathology, Brigham and Women’s Hospital, and Harvard ...